I-high-purity shark chondroitin sulfate iyisithako esibalulekileyo sokunakekelwa kwezempilo ngokubambisana
I-Chondroitin sulfate (CS) yi-glycosaminoglycan ebalulekileyo edityaniswa ngokudibeneyo kwiiprotheni ukwenza i-proteoglycans.Isasazwa ngokubanzi kwi-matrix ye-extracellular kunye ne-cell surface yezilwanyana zezilwanyana, kwaye iyingxenye ebalulekileyo yezilwanyana ezixhamlayo zezilwanyana, ezigqithiseleyo kwi-cartilage.Isiseko esisisiseko se-chondroitin sulfate senziwe ngokutshintshana kwe-D-glucuronic acid kunye ne-N-acetylgalactosamine ngamabhondi e-glycosidic, adityaniswa ngakumbi kwinxalenye ephambili yeprotheni ukwenza isakhiwo esiyinkimbinkimbi seproteoglycan.
I-Shark-derived chondroitin sulfate yenye yazo, i-acidic mucopolysaccharide substance elungiselelwe kwi-shark cartilage tissue.Kubonakala njengomgubo omhlophe okanye omhlophe, akukho vumba, incasa engathathi hlangothi.I-Chondroitin shark sulfate yenye yezona zinto ziphambili ze-mammalian connective tissue, kwaye ifumaneka ngokubanzi kwi-cartilage, ithambo, i-tendon, i-ligaments, i-sarcolemma, kunye neendonga zemithambo yegazi.
Isebenza njengokugcinwa kunye nenkxaso kwi-articular cartilage.Ukutya okuphakathi kwe-chondroitin sulfate kunokunceda ukugcina izicubu ze-cartilage, ukunciphisa ukuvuvukala kunye nentlungu, ukuphucula ukungasebenzi kakuhle kwamalungu, kunye nokhuseleko oluphezulu.Ihlala isetyenziselwa kunye ne-glucosamine, indibaniselwano ephucula kakhulu iklinikhi ephakathi ukuya kwiintlungu ezinzima kwi-osteoarthritis kwaye ivuselela i-collagen entsha kunye ne-proteoglycans kwi-chondrocytes.
| Igama lemveliso | Shark Chondroitin Sulfate Soidum |
| Imvelaphi | Imvelaphi kaShaka |
| Umgangatho woMgangatho | USP40 Umgangatho |
| Imbonakalo | Mhlophe ukuya kumgubo omhlophe |
| Inombolo yeCAS | 9082-07-9 |
| Inkqubo yokuvelisa | inkqubo enzymatic hydrolysis |
| Umxholo weProtheyini | ≥ 90% yiCPC |
| Ilahleko ekomisweni | ≤10% |
| Umxholo weProtheyini | ≤6.0% |
| Umsebenzi | Inkxaso yezempilo edibeneyo, iCartilage kunye neMpilo yeBone |
| Isicelo | Izongezo zokutya kwiThebhulethi, iiCapsules, okanye uPowder |
| Isatifikethi seHalal | Ewe, iHalal iqinisekisiwe |
| Ubume be-GMP | I-NSF-GMP |
| Isiqinisekiso sempilo | Ewe, isatifikethi seMpilo sikhona ngeenjongo zokufumana imvume |
| Beka ubomi kwishelufa | Iinyanga ezingama-24 ukusuka kumhla wemveliso |
| Ukupakisha | 25KG/Drum, Ukupakishwa kwangaphakathi: I-PE BAGS ephindwe kabini, ukuPakisha ngaphandle: Igubu lePhepha |
| INTO | INGCACISO | INDLELA YOVAVANYO |
| Imbonakalo | I-off-white crystalline powder | Okubonakalayo |
| Ukuchongwa | Isampulu iqinisekisa kunye nethala leencwadi | Nge-NIR Spectrometer |
| I-spectrum yokufunxa nge-infrared yesampulu kufuneka ibonise ubukhulu kuphela kumaza afanayo naleyo ye-chondroitin sulfate sodium WS. | Nge-FTIR Spectrometer | |
| Ukwakheka kweedisaccharides: Umlinganiselo wempendulo ephezulu kwi△DI-4S ukuya △DI-6S ayikho ngaphantsi kwe-1.0 | Enzymatic HPLC | |
| Ukujikeleza kwe-Optical: Ukuhlangabezana neemfuno zokujikeleza kwamehlo, ukujikeleza okuthe ngqo kwiimvavanyo ezithile | I-USP781S | |
| Isivavanyi(Odb) | 90%-105% | HPLC |
| Ilahleko Ekomisweni | < 12% | USP731 |
| Iprotheni | <6% | USP |
| Ph (1%H2o Isisombululo) | 4.0-7.0 | USP791 |
| Ukujikeleziswa okuthe ngqo | - 20 ° ~ -30 ° | I-USP781S |
| Intsalela kwi-Ingition (isiseko esomileyo) | 20%-30% | USP281 |
| Organic Volatile Residual | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| I-Chloride | ≤0.5% | USP221 |
| Ukucaca (5%H2o Isisombululo) | <0.35@420nm | USP38 |
| Ukucoceka kwe-Electrophoretic | NMT2.0% | USP726 |
| Umda we-disaccharides ethile | ＜10% | Enzymatic HPLC |
| Iintsimbi ezinzima | ≤10 PPM | I-ICP-MS |
| Ukubalwa kwePleti iyonke | ≤1000cfu/g | USP2021 |
| Igwele kunye noMngundo | ≤100cfu/g | USP2021 |
| Salmonella | Ukungabikho | USP2022 |
| E.Coli | Ukungabikho | USP2022 |
| Staphylococcus Aureus | Ukungabikho | USP2022 |
| Ubungakanani beNcam | Yenzelwe ngokweemfuno zakho | Endlini |
| Unizi lolwapho kuyiwa khona | >0.55g/ml | Endlini |
Okokuqala, i-chondroitin sulfate yi-glycosaminoglycan efumaneka ngokubanzi kwi-matrix ye-extracellular yezicubu.Kwithambo, ifumaneka kakhulu kwi-periphery ye-chondrocytes kwaye iyinxalenye ebalulekileyo ye-cartilage extracellular matrix.I-substance inceda i-cartilage ifumane amanzi kunye nezondlo, ngaloo ndlela igcina i-cartilage enomanzi kunye ne-elastic, kwaye inceda ukugcina umsebenzi oqhelekileyo wamalungu.
Okwesibini, umphumo we-physiological we-chondroitin sulfate ubaluleke kakhulu kwi-articular cartilage.Iyakwazi ukubopha iamolekyu zamanzi, ifake iimolekyuli zamanzi kwiimolekyuli zeproteoglycan, igxininise i-cartilage kwaye inyuse inani le-synovial fluid kwindawo edibeneyo, i-lubricating kunye nokuxhasa i-joint.Ngale ndlela, umdibaniso unokunciphisa ukungqubuzana kunye nefuthe xa uhamba, ukwenzela ukuba umdibaniselwano unokuhamba ngokukhululekile.
Ekugqibeleni, i-chondroitin sulfate iphinda isebenze kubunjineli bamathambo.Abaphandi baye balungiselela i-hydrogels edibeneyo esekelwe kwi-chondroitin sulfate, ebopha ngokuzimeleyo i-ion ye-inorganic kwaye ivuselele i-bone biomineralization, ngaloo ndlela iphucula amandla okuhlaziya amathambo.Oku kunezicelo ezibalulekileyo zotyando lweklinikhi lwamathambo olufana nokulungiswa kwesiphene samathambo kunye nokufakelwa kwethambo.
1. Ukukhuthaza impilo edibeneyo: I-Chondroitin sulfate yenye yezona zinto ziphambili ze-articular cartilage, ezinokunceda i-articular cartilage igcine i-elasticity kunye namanzi, kwaye ngaloo ndlela igcine umsebenzi oqhelekileyo wokudibanisa.Ngokuncedisa i-chondroitin sulfate, inokukhuthaza ukulungiswa kunye nokuvuselelwa kwe-articular cartilage, ngaloo ndlela iyancipha inkqubo yokudibanisa ngokubambisana.
2. Ukunciphisa intlungu edibeneyo: i-chondroitin sulfate inokunciphisa impendulo yokuvuvukala kwi-joint, ukunciphisa ukukhuthazwa kwe-synovium edibeneyo, kwaye emva koko iyancipha intlungu edibeneyo.Oku kunempembelelo ebalulekileyo yokunciphisa intlungu kwizigulane ezinezifo ezidibeneyo ezifana ne-arthritis.
3. Ukuphucula ukuhamba ngokubambisana: I-Chondroitin sulfate iphucula ukuhamba kunye nokuguquguquka kokubambisana ngokunyusa i-lubrication edibeneyo kunye nokunciphisa ukudibanisa.Oku kwenza ukuba ukudibanisa kube lula ngexesha lokunyakaza, ukunciphisa ukuphazamiseka okubangelwa ukuqina kwamalungu okanye ukunyakaza okulinganiselwe.
4. Khusela i-articular cartilage: I-Chondroitin sulfate inokuthintela ukuthotywa kwe-articular cartilage, kwaye ikhuthaze ukudibanisa kunye nokukhupha i-chondrocytes, ukwenzela ukuba idlale indima ekukhuseleni i-articular cartilage.Oku kunceda ukulibazisa inkqubo yokuguga ngokubambisana kunye nokuncipha.
1. Ukuphulukiswa kwesilonda kunye nokulungiswa kwesikhumba: I-Chondroitin sulfate idlala indima ebalulekileyo kwinkqubo yokuphulukisa isilonda.Inokukhuthaza ukuvuselelwa kunye nokulungiswa kwezicubu zenxeba, iphucule i-elasticity kunye nokuqina kolusu, kwaye incede ekunciphiseni ukubunjwa kwamanxeba.Ngoko ke, i-chondroitin sulfate inezicelo ezinokubakho kwiinkqubo zokuhlinzwa, ukutshisa unyango kunye nokulungiswa kwesikhumba.
2. Imboni yezimonyo: Ngenxa yezinto ezintle zokuthambisa kunye nefuthe lokuguga, i-chondroitin sulfate isetyenziswa ngokubanzi kwishishini lezimonyo.Ingongezwa kwiimveliso zokunakekelwa kwesikhumba njengesithako esithambisayo, inceda ukugcina ibhalansi yokufuma kwesikhumba kunye nokuphucula ukuqina kwesikhumba kunye negloss.Ukongeza, i-chondroitin sulfate inokuthintela ukuveliswa kwee-radicals zamahhala, icothise inkqubo yokuguga kwesikhumba, kwaye yenza ulusu lube luncinci kwaye lube nempilo.
3. Ubunjineli bezicubu kunye neyeza lokuvuselela: Kwintsimi yobunjineli bezicubu kunye neyeza lokuvuselela, i-chondroitin sulfate isetyenziswe njengenxalenye yokwakhiwa kwezinto ze-biomimetic stent.Inokudibaniswa kunye nezinye izinto eziphilayo ukwenza i-scaffolds enezakhiwo ezithile kunye nemisebenzi yokulungiswa okanye ukutshintshwa kwezicubu ezonakalisiweyo kunye nezitho.I-biocompatibility kunye ne-bioactivity ye-chondroitin sulfate yenza ukuba ibe ngumviwa obalulekileyo kwintsimi yobunjineli bezicubu.
4. Impembelelo ye-Antitumor: Kwiminyaka yakutshanje, uphando lufumene ukuba i-chondroitin sulfate nayo inamandla okulwa ne-antitumor.Inokuthintela ukuqaliswa kwe-tumor kunye nokuqhubela phambili ngokulawula ukukhula, ukwahlula kunye neenkqubo ze-apoptotic zeeseli ze-tumor.Nangona uphando olufanelekileyo lusekwinqanaba lokuqala, ithemba lesicelo se-chondroitin sulfate kwintsimi ye-anti-tumor kulindeleke.
I-Chondroitin sulfate kunye ne-glucosamine sulfate azikho uhlobo olufanayo.Kukho iiyantlukwano ekubunjweni kwazo, ukusetyenziswa kunye nendlela yokwenza.
I-Chondroitin sulfate yi-glycosaminoglycan enemisebenzi eyahlukeneyo yezinto eziphilayo, kuquka i-lipid-regulating and anti-inflammatory effects.Isetyenziswe ngokubanzi kunyango lwe-osteoarthritis kwaye iyakwazi ukunciphisa abalamli abavuthayo kunye neenkqubo ze-apoptotic, ngelixa ngaxeshanye kunciphisa ukuveliswa kwee-cytokines ezivuthayo, iNOS kunye ne-MMPs.Ngaphezu koko, i-chondroitin sulfate nayo idlala indima ebalulekileyo ekukhuseleni nasekulungiseni i-articular cartilage, inceda i-cartilage ukuba imelane noxinzelelo lwe-tensile phantsi kweemeko ezahlukeneyo zokulayisha ngokwenza i-tissue resistant and elastic.
Kwaye i-glucosamine sulfate yenye i-compound ebalulekileyo, eyona nto isetyenziselwa ukuthintela kunye nonyango lweentlobo ezahlukeneyo ze-osteoarthritis, ezifana nedolo kunye ne-hip joint.Isebenza kwi-articular cartilage, ngokuvuselela i-chondrocytes ukuvelisa i-proteoglycans kunye nesakhiwo esiqhelekileyo se-polysome, ukuphucula amandla okulungisa i-chondrocytes, inqanda umonakalo we-cartilage enzymes ezifana ne-collagenase kunye ne-phospholipase A2, kwaye inokuthintela ukuveliswa kwe-superoxidized radicals mahhala kwiiseli ezonakalisiweyo, ngaloo ndlela ukulibazisa. inkqubo ye-pathological of osteoarthritis kunye nenkqubela yesifo, ukuphucula umsebenzi odibeneyo, ukukhulula intlungu.
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